Episode 192-Fasting-Mimicking Diet for Aging Well w/ Dr. Joseph Antoun (L-Nutra)

In this episode of the Aging Well Podcast, Dr. Armstrong speaks with Dr. Joseph Antoun, CEO of L-Nutra, about the Fasting Mimicking Diet (FMD) and its potential to enhance longevity. Discover how FMD works, its benefits for cellular repair and metabolic health, and how it stands out from traditional fasting methods. Dr. Antoun shares insights on the typical FMD regimen, who can benefit most, and any associated risks. Learn how FMD compares to other dietary strategies and explore future research directions in this fascinating discussion. Tune in for practical advice and scientific insights on optimizing your health and… aging well.

Links:

https://l-nutra.com

https://prolonlife.com

https://l-nutrahealth.com

https://drjosephantoun.com

At LinkedIn and X @drjosephantoun.com

The Longevity Diet by Valter Longe

TruDiagnostic epigenetic testing
Get a 12% discount using promo code (AGEWELL) and track your pace of aging well.

Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.

Transcript

0:04

Welcome to the Aging Well Podcast. In this episode, we welcome Dr. Joseph Antown, CEO of L Neutral, to discuss the transformative potential of the fasting mimicking diet for aging well. Dr. Antown shares the science behind the fasting mimicking diet. How it differs from traditional fasting and its specific benefits for aging, such as promoting cellular repair and metabolic health. The conversation also covers the typical regimen of the fasting mimicking diet, who can benefit most from it, and the potential risks.

jeff_1_09-05-2024_100648: 0:34

Welcome to the aging well podcast. Let's begin by having you tell us a little bit about yourself and the company you lead L-Nutra. All

squadcaster-4i9i_1_09-05-2024_100649: 0:42

But thank you very much, for hosting me today. Hopefully we're going to change somebody's life after this discussion. That's always my goal. I started my career as a physician. I always wanted to treat patients. when I started practicing, I realized that I was trained to give people pills for the rest of their lives. Some of them are helpful. Some are just barely controlling the condition. So, you know, for a cardiologist, typically you give people a pill for cholesterol, a pill for triglyceride, a pill for blood pressure, And there is no end date on that prescription, It has to be refilled every month. And so it's practicing sick care at its best. You meet people after they're sick and keep them controlled sick for the rest of their life. I didn't want that. I didn't want to subscribe to that system. so I left and did my studies in health policy and public health, I thought I'll support, preventive measures, and advocate, digital health systems to be more preventative. doing that helped me set some policies and some preventive policies, but on average, people know that they should eat healthy, that they should exercise. So it wasn't, it wasn't a disruptive prevention, you know, model. I started looking around the world for a product or something that is a technology that we can consume or we can practice or we can do to, to reverse the diseases, the chronic diseases and or to prevent them. And then two aha moments changed my life The first was about aging. And discovering that aging is the mother of all or most chronic disease that will kill us, right? 90 percent of us will die out of one of four conditions. Diabetes, cancer, cardiovascular, and Alzheimer's. 90 percent of us. you, me, and most of people listening to us today, remember you're going to die with 90 percent chance out of one of these four health conditions. I was like, whoa, that's the number one killers by far. And guess what? They all are the expression of aging in medicine. We, they don't teach us that. They teach us about each, each vertical is different. Alzheimer's is different. Cardiovascular is different than diabetes. Each one has, different reasons, different specialty, but we don't get a heart attack at age 20. We don't get Alzheimer's at age 25, right?

jeff_1_09-05-2024_100648: 2:57

right.

squadcaster-4i9i_1_09-05-2024_100649: 2:58

And so all of them are age related and driven by the body getting older and the cells doing mistakes and us not being able to deal with correction and rejuvenation and fixing what's going wrong we become prone to one of these health conditions and then we die of them. my biggest aha moment, was The biological age of the body is the most important unit of measurement of health that we need to focus on, If you're 70 chronologically, but you're 50 biologically, you're 20 biological years away from a higher risk of Alzheimer's cancer or diabetes. So that changed my perspective and the biological age of the body became my focus. And number two, I was like, can we reverse the bio age? Can we slow down aging? And the answer was, of course, and but one of the ways that is the most effective, my biggest second biggest aha moment was how to do that with nutrition with food. Because food is the only product everyone consumes every day of their life from the day they're born to the day they're gonna die and is the only product that we comply to and consume all the time. So my passion became how can we tailor food? to become an asset of longevity or an asset of reversing the age of the body or treating health conditions. And this is how I launched my career in nutrition technology. can we put evidence based trials to develop novel food formulations that can reverse the bio age of the body or help patients get, you know, get them out of or help them achieve a remission out of the four big killers.

jeff_1_09-05-2024_100648: 4:40

Well, this is right up the alley of the Aging Well podcast, because we tend to promote our five pillars, which are now six pillars, we have exercise and physical activity, diet sleep, having good sleep hygiene maintain a healthy body composition, which diet fits in with that, not smoking. And then finally, we've added kind of purposeful, healthy. Social connections,

squadcaster-4i9i_1_09-05-2024_100649: 5:07

Very important.

jeff_1_09-05-2024_100648: 5:09

I've learned this. I teach a pathophysiology and exercise class and that teaching all these different diseases. It's like there's a commonality here. If we get moving, we get eating right, we get sleeping right. We don't smoke. We do all these healthy things. We're not going to get sick, right? So how does fasting and caloric restriction play a role in aging?

squadcaster-4i9i_1_09-05-2024_100649: 5:32

So I agree with you on the five pillars. And I love the fact that you add the purposeful, we call it social capital, or anything related to receiving emotions and love or giving emotions and love with friends, family, being well suited. we study centenarians, people living 100 and beyond, and the most common factor to them is they're happy, they're well nested in their families, they still live in their houses in the village or close by, so day to day happiness is very, very important. But the second very important intervention is the fasting impact or caloric restriction. there's no centenarian. person living above the age 100 that we found that was all their life, you know, eating unhealthy or overweight or not practicing the balance of eating periods and fasting periods. It turns out these are very important for the balance to be eating and not eating. And so we started, we started studying fasting a few hours of fasting, one day of fasting, two days of fasting, three days, four days, five days, et cetera. We gathered 18 universities. USC is a longevity Institute at the University of Southern California. It was the first one. And then we brought in Stanford and Mayo Clinic University of Indiana, University of Genoa, Palermo. We put a big network of 18 universities to study with the same way that we develop medicine to study what happens with fasting. And now we evolved to do the fasting nutrition, what we're going to talk about to summarize this topic, because A lot of people talk about fasting, but few of them have really read the science and understand what happens there. So I want to clarify this for our audience. In general, if we zoom out, there's two phases of fasting. There's the first two days, we call it intermittent fasting. Between zero hours to 48 hours. And then above two days, day three and above, you call that periodic or prolonged fasting. So why the cutoff? Why the two days cutoff? Because the first two days, the body has enough metabolic reserves to compensate for the fast. I'll give you an example. imagine the body reacting to fasting the same way as if you own a company and the company needs, you know, revenues to survive. Okay. So if a company that needs a million dollar now has 0 instead of a million, it's like the body fasting. The first thing that the CEO does, he goes to the bank and says, I have, a checking account that can tap clearly into the body taps the first few hours into glycogen is the fastest reserve they can go for. Now, if you deplete your checking account, you're going to lean on your savings account. And the body does the same thing goes to fat and breaks down fat into ketones to nourish the brain and other organs. Now, once you deplete your checking and savings account, you're going to lean on your credit card or ask for a loan from the bank. And this is what the buddy asks. So savings account is over the first night, and now you're in day two and you're tapped into the credit or the loan in the body, which is the liver. The liver can do a neoglucogenesis, produce some calories and dump them into the body. That's your loan from the bank. And this happens end of day two. So first day glycogen, then ketones around end of first day, next days, and all the way end of second day, your, your, your delivery is helping. Day day two is done, and now you're in day three. Again, you're the sea of the company. You, you depleted your cache. What you're gonna do, you're gonna restructure the company. You're gonna say, I'm in a crisis. I'm gonna fix everything going wrong in operations to survive one other day. So you're going to align, you're going to cut everything that's not necessary to the business optimize how you operate, optimize, employees, et cetera, et cetera. And the body does the same thing. We are made of 37 trillion cells that are all dependent on calories. when you're fasting, the cells are practicing a self rejuvenation process after day three that we call autophagy or self rejuvenate. And they're trying to detox, they're trying to fix everything going wrong, and, and they, even the epigenetics of an embryonic or rejuvenative cells is triggered as well. This process of auto G one de Nobel Prize in medicine in 2016, it's very important to understand that it happens at day three. It doesn't happen after 16 hours because everyone doing 16 eight, they're thinking that they're getting autophagy. you haven't even depleted your glycogen. You still have fat, you still have the liver. So skipping breakfast in the morning, sorry to spoil this for many is not going to take you into autophagy is going to help you, you know, pace your weight. You're going to definitely tap into the reserve. So your bank account will drop. You do it every day. So you're, you improve your fat, you improve your metabolic health, which is great for blood sugar, for blood pressure, for cholesterol, but you're not going to go into the rejuvenative. age reversal part of fasting, you got to cross the day three, you got to go through that crisis of cellular rejuvenation that we call autophagy. So then we started day four, day five, and then even the stem cells get activated around day five. You know, this is the CEO saying, now I got a little bit reshuffle also the team and deeper structure. So if you go long enough, now you're bankrupting the company. So the ideal, If you want to do fasting for metabolic reset and cellular rejuvenation, the ideal period is five days. And my five days comes at a pain. That CEO had to fix the company, you know, has to go through a lot of pain and doesn't have money to even order supplies for next month. Doesn't even have money to keep the lights on. we have worked very hard 12 years, 48 million in research and development to develop this fasting nutrition, the fasting mimicking diet, we call it. Can we nourish the body in a specific formulation that the cells would not recognize? And therefore you're getting the benefits of fasting while you're eating food. So you're making the process much less risky, much less painful, and you're making it even more rejuvenative, even more healthy on the body. It's like telling the CEO, I'm going to give you half a million daughter. You need a million. I'll give you half a million. There's still a pressure of half a million to correct, but at least he can pay. the best people he has in the company can order his supply. You can still do the activities that he needs to run the company. And this is how the fasting and diet was born to provide this autophagy and rejuvenation to the body.

jeff_1_09-05-2024_100648: 12:12

So there's really quite a bit of difference between and we often hear people kind of the the big thing now is intermittent fasting and the reality of intermittent fasting as I understand it, is it is helpful for losing weight because you go into a more caloric restrictive state, but it isn't much different in the long run than just simply a more spread out caloric restriction, right?

squadcaster-4i9i_1_09-05-2024_100649: 12:40

So let me go through the science of intermittent food. So you're right. It's a metabolic balance. We call it is to help the body reach the metabolic balance rather than eating all the time and stacking fat all the time, especially after age 40, where it's difficult to get rid of it. it's important to do it at around that age and beyond, but some people are practicing the wrong intermittent fasting and this is very important to talk about because if you read the intermittent fasting science, there's some positive data and then some negative and everyone is confused. And let us explain this confusion. is what I call the front ended meaning. I start early. I eat my dinner at six. I eat my dinner at seven. And then you can stay all night overnight, uh, um, without food. And then you can still have your breakfast at eight or nine or 10 a. m. So you've done your 12 to 14 hours, but you've done it by eating your dinner early. And that's the intermittent fasting that consistently does better on longevity, on weight loss. There's an intermittent fasting that does even worse on longevity and weight loss, which is the back ended one. A lot of people, because that's the practice of life, we get laid back from work and we have still things to do and we get a late dinner and then we snack or we watch TV and then we snack again and then eating at 10 and 11 p. at night, which is the worst thing you can do for your longevity. This is one of my biggest messages here today. If you want to change one thing in your life and have a major impact on longevity is the dinner. You know, late dinner is just. is so damaging to the body that it even makes intermittent fasting unhealthy in the long term. So you're eating late at night and you're sleeping. The body sees excess calories, right? You're sleeping, you're not spending the calories and your body overnight is anabolic. Growth hormone increases in the morning, cortisol is increasing and insulin is increasing. So the body at night is ready to rejuvenate and store. And you're feeding the body late at night. So The excess calories goes into fat, into higher inflammation. With aging, it's inflammation. Now, the next day, those people wake up in the morning and say, Hey, I never have appetite in the morning. Of course, because you eat late yesterday. And then they stay without food. And again, that's the practice of life. You know, you go to work and you're too busy. And then, and then they stay all the way to 4 or 5 p. m. And this is when they indulge on food. They eat at 4 and 5 and then snack late again. That practice of intermittent fasting, where you're eating a little bit late, you're starving the body during the day, where the body actually needs the calories. In the morning you go to work, you're thinking, in the morning going to the gym, you're walking throughout the day, you need to perform, and you're starving your body there. And then you eat again when the body doesn't need the food. the trials that are observational on intermittent fasting, they observe people, most people do, who do intermittent fasting by practice, eat late at night, don't eat during the day and then we see bad results. The randomized intermittent fasting trials where we tell people stop your dinner at seven and still have a breakfast or just delay your breakfast till nine and then they do very well as health outcomes. So I wanted to clarify that point and clarify the science of intermittent fasting. We recommend you do your dinner early. We recommend you eat something in the morning because your major essential health organs are working. The heart is pumping faster because you're going to work, exercising, walking, your brain needs calories, feed them in the morning, let them rest at night, we call that circadian fasting 12 to 14 hours. That's the way to go in healthy longevity, matching fasting with healthy longevity.

jeff_1_09-05-2024_100648: 16:22

Okay, we know that physiology, especially in animal studies, that caloric restriction is great for longevity. How do you define caloric restriction? Because it's a little bit different in animals, I think, than it really is in humans. how do you go about defining that for longevity? Yeah,

squadcaster-4i9i_1_09-05-2024_100649: 17:09

the eating less than, and again, it depends on your BMI and your age But whenever you eat less, you're in calorie restriction. Some people say 10, 20, and some people went all the way to 30%, like the biosphere, within the biosphere. I don't know if you're familiar with the Roy Waldorf experiment and the biosphere experiment. It was a chronic, very low calorie setting. Just to see what happens to the body and, and, and it was, it was, it was a pretty powerful outcome. so the, the, your question is a, is a, it will take two podcasts to answer because, because it's age dependent. It's very important that, you know, what you do between age 40 and 65 is very different than what you need to do after age 65. After age 65, calorie restriction is as good as bad, right? This is when your muscle gets lost very fast. This is where you don't absorb your food right at that age, so calorie restriction quickly decreases the energy coming to the body. Between age 40 and 65 is where most diseases started forming. Cancer starts at that age. Cancer doesn't start at 75 80 because it sells. They don't replicate at that age to be mistaken. There's two cancers, the age 40 to 65 and age 40 to 65 is where most plaques and with high inflammation where you get the acute coronary artery syndromes, etc. So between age and 40 and 65, it's it. This is the age where you can practice color restriction. We don't like the chronic color section. We like the words eat a little bit less or eat right on norm. Practice intermittent fasting. Same way as we talk about exercise, right? Consistent exercise. Do some intensive exercise. This is the combination that's showing to be pro longevity, big time. Most centenarians again when you talk to them, were pescetarian. They were flexitarian. They added meat a little bit. Just with the stews, it's not like they were eating big steaks, and they were not severely calorie restricted, but they were not overeating consistently.

jeff_1_09-05-2024_100648: 19:11

I like that definition. I think that fits very well. what are the main health benefits of the fasting mimicking diet, particularly in the context of aging?

squadcaster-4i9i_1_09-05-2024_100649: 19:22

So, it is actually positioned for aging. The fasting mimicking diet, going back, is to the first part of the discussion. The goal is to give you food so that you go through five days of fasting. That's the entire objective. We call the product Prolon. Prolon gets shipped to your house, you open that box and you have day one, day two, day three, day four, and day five. You're eating the food, you have all the foods, all the liquids that you need, and you have your supplements as well. So it's full food, drinks, and supplementation for five days. And you do it to simulate to your body as if you're fasting. And so it doesn't spike the anabolic, insulin and growth factors. On the cellular level. It doesn't trigger the nutrient sensing pathways. So we studied how the cell senses food through three nutrient sensing pathways, the tour, the P. K. And the rest and the diet does not over stimulate those pathways. So your body is fasting while you're consuming food and we see five major benefits with that. Number one benefit is the bio age reversal off the cells. We just published four months ago in nature. the number one Science Journal of the World, we published that if you do Prolon three times per year, 15 days, and please, for everyone listening 15 days throughout the year, only three times, you actually reverse your bio age by 2. 5 years. If you do it every year three times, between age 50 and 70, you reverse your bio age by 11. 5 years. So 2. 5 within the first year, and then, and, The benefits decrease with time and then it gets to, if you do it consistently three times per year between age 50 and 70, there's 11. 5 bio age reversal. This is critical why we started the discussion today by saying it's the internal age of the cells and metabolism that define the onset of chronic conditions. So on this podcast called the Aging Love Podcast, you're doing prolonged fasting. With a fasting mimicking diet, we don't recommend you do it with water because it's too difficult. Most people cannot. And it's important to nourish while you're fasting. Very important. And if you do it three times per year, you expect to reverse your bio age by 2. 5 years. It's published by the number one science journal of the world. We have 40 clinical trials behind the fasting mimicking diet now. All in, major universities USC, Stanford, UCLA, Mayo Clinic, University of Indiana, University of Miami. University of Palermo, Genoa, Berlin, Charite, 18 universities are doing this data trials with us. So bio age reversal first benefit. Second benefit, which a lot of people love is the weight loss, right? Imagine your buddy thinking you're fasting. We talked about your bank account that gets depleted super fast. if you don't have revenues, it's the same way. Fasting is like one of the fastest, actually it is the fastest way to lose weight because you're fasting. So you lose a lot of weight. There's something critical to know here, which is that, a lot of people now are on either chronic diets or they're using the GLP 1s, you know, the Wachovis, the Ozempics, the GLP 1 agonist. When you inject the GLP 1s agonist or when you do chronic calorie restriction, you actually lose fat and muscle, right? This is something we didn't talk about with chronic calorie restriction. When you lose fat and muscle and you stop at a certain point, because you start a diet, you stop one day, you inject yourself every week with the, and soon you're going to have the pills. Once you stop, the metabolic rate has decreased because you decreased the muscles. Like the engine of the car is now less powerful. So whenever you go back and eat food again, you store it in fat super fast and gain back your fat, gain back your insulin resistance, and go back worse than when you started. we hear this all the time, everyone listening to us here, remember that Ozempic was first approved in 2017 for diabetes and never solved diabetes. People go on it, and the day you stop it, you lost so much muscle. The study showed that you lose 25 up to 40%, but 25 to 30% is the norm of muscle loss that you incur with the, with the GLP ones. And the day you stop it, you gain back the fat fast because, the muscle has decreased so much that it cannot burn the carbs you're eating again. With the fasting mimicking diet, the muscle function is maintained. this is very important, and we have two clinical trials on this, and we have a five pattern on this. Why the muscle only gets maintained, the muscle function, within the fasting mimicking diet of five days? Because Fasting acts as a stress, not as a depletion. The five days is not a depletion, it's a stress on the cells. This is why they rejuvenate. The stress hormones in the body, one of the stress hormones is growth hormone. So growth hormone increases when you're doing prolonged, and so it's telling the muscle to grow. Now, with the fasting mimicking diet, you're eating food, so there is proteins, there are proteins circulating for the muscle to grow, and the muscle is practicing autophagy rejuvenation. So you have a muscle in rejuvenation. You're feeding that muscle and the growth hormones are telling the muscle to grow. This is how it gets balanced and maintained. And this is critical because it helped us unlock diabetes. We have a version of the prolon. We mentioned the, the prolon is the name of the product, the fasting lubricant night. We have a version called a neutral health. And that version is to reverse diabetes. We have shown that every six months on average, A person can decrease the dose of medication or even take off the full medication when you do the fasting mimicking night once a month, every six months, meaning in 30 days in total, five days, month one, five days, month two, three, four, five, and six. It's helping you within just 15 days to decrease one medication or one dose every time. And the secret was getting younger again, diabetes type two is with age, you're getting biologically younger. You're losing a lot of fat, as we said, you lose super fast the fat, and you're protecting muscle, so you're burning the carbs still at a good rate rather than decreasing that. There's no medication in diabetes today that works on that. They all deplete the sugar, or they all deplete the muscle, and this is why we unlocked, diabetes regression remission with the fasting mimicking diet. The program is called L NutriHealth, L NutriHealth. com if you want to find, more information about it.

jeff_1_09-05-2024_100648: 25:46

we'll include all those links in the description this doesn't sound right because medicine is supposed to react to disease. rather than trying to be proactive and prevent disease. So you just got to be throwing people off here as they listen to this like, wait a minute, drugs don't work. I got to actually do something to change my body and it works to make me healthier. What a novel idea. and that's, our focus here on the Aging Well podcast we want to get people focused more on being proactive in aging as opposed to being reactive. we hear so much about biohacking in the longevity circles and all that And it's all things that are designed to supposedly reverse the aging process. But it sounds to me what we're talking about here is trying to slow that aging process. And when we have put ourselves in front of the eight ball, we can adjust and get back on track to aging.

squadcaster-4i9i_1_09-05-2024_100649: 26:43

For sure, Jeff, and I think what's most important in here today, is you have a scientific company doing this. That's critical because the great thing about biohacking is it's a venture movement some of it gets it right, some of it not. The medicine and the sick care system today, I mean, it's, it's good for a few things. It's not good for a long, for a lot of longterm things and definitely not good in prevention yet. So. The solution is why we like nutrition, because it's the only product we consume every day. It's, either the best longevity asset or the, the, the worst poison you can have, because you've taken it every day of life. We turned it as a poison in the U. S., and we said, it's okay, we'll give you drugs after that. Once you're diabetic, we'll give you a drug, and if you're obese, I'm gonna inject you with GLP 1, and if you get Alzheimer's, we'll swap the drugs with another drugs. That doesn't work. And we were okay with that. And we're the first company to say, we're going to say no to three things. We're going to say no to sick care because we're going to start early. We're going to say no to just treating symptoms. We're going to treat the true causes, the root causes of diseases, which is aging. Nobody's treating aging today in a scientific way and insulin resistance and fat and protecting muscle. And number three, we're going to help people practically do something that they can do every day. They don't have to inject. artificials and biologics and chemicals in their body. Let's use a plant based, healthy solution to help their body reach their optimal longevity. we enveloped all this with science. This is what's most important. It took us 23 years of research before we started selling the first product. You don't hear this in any nutrition company or supplement. Typically, it's a book, it's an idea, and then we go to market. It's like intermittent fasting. They told us you skip breakfast, you get autophagy after 16 hours.

jeff_1_09-05-2024_100648: 28:31

all

squadcaster-4i9i_1_09-05-2024_100649: 28:31

It's all wrong. it's just got to start with the science. You got to do lab trials to make sure you prove the concept in mice the same way we develop drugs. Then you go to clinical trials. You do phase one phase two and phase three in nutrition. you've got to do it in a randomized clinical trial way. You've got to do it in big universities to make sure that this is a third party, it's validated. And this is what we've done. It took us, 100 million in raise. It took us 23 years. And now we have 40 clinical trials. We have 134 issued patents. Prolon is the only product in history, in nutrition, to have a patent on promoting longevity. the fasting mimicking diet has multiple patents on treating Alzheimer's, on treating cancer, on treating autoimmune diseases, on treating diabetes. We're still in trials for many. We know we can induce diabetes regression remission. We've got the results of these trials. We know we can help certain people with cancer optimize nutrition around their chemotherapy and immune therapy. We're waiting for the results on autoimmune. We're waiting for the results on Alzheimer's. But. At least you're, you're doing something for five days only, plan based, has science, has patents, has publications. we're trying to optimize nature and tailor nature to our advantage and have something that's healthy for the planet and for the lives that live within it.

jeff_1_09-05-2024_100648: 29:50

And I would note for the listeners and viewers that if they're interested in the research, you link it on your website. I pulled up, a whole big file. I never got through it all before our interview, uh, because it's pretty extensive. The literature is all there, and it's not literature that is remotely off on the side, but we can still kind of link it in here is science behind our product. It is literally dealing with fasting, mimicking diets. I encourage the listener if they want more information to go to the website and read some of the journal articles. that's one thing I found very favorable about your company You present some real science there. I've seen products where I go into looking at their, their list of references and it's like, wait a minute, this doesn't really fit with this product. They're just kind of, remotely related. You know, it's like, we know exercise helps you lose weight. So they have an article in there about exercise and losing weight, but it has nothing to do with fasting

squadcaster-4i9i_1_09-05-2024_100649: 30:49

Yes. They always do that. they show you side trials. They show you correlative trials because it's expensive to do clinical trials and you have to wait for a long time. the kudos goes to our founder, professor Walter Longo. A lot of listeners probably here know that name Walter Longo. If you ask Chat GPT, who is the top, you know, global, leader in longevity and nutrition, you'll get Walter Longo. I recommend you read his book, the Longevity Diet, Amazon Bestseller in the Longevity Diet. He helps you understand what to eat, to age healthy and age well. if you have a disease, there's a chapter. If you have diabetes, if you have cancer, if you're Alzheimer's, what to eat to optimize your, your body around the treatment of these conditions. he was ethical enough to wait for 20 years, two decades. He's the head of the Longevity Institute at USC. University of Southern California was a big backer of this Longevity nutrition movement. then 17 other universities came together and formed the first network of medical centers doing research on nutrition for longevity. this is where we have now 40 clinical trials. I'm happy you said you couldn't go over all of it because it is extensive science and research. And we do it randomized. It's not a case report or a small trial here and there. These are big medical center universities doing trials and they're all randomized, IRB approved. I don't want to get very technical, but a big check on science first and this is what our genetics. and then you can see how many profiles that this company, are made of. So, yeah,

jeff_1_09-05-2024_100648: 32:22

you mentioned three times a year is the ideal, so a total of 15 days. Some listeners or viewers might be saying, well, if three is good, is four more or five more or six more? Is there any better benefit of increasing the frequency of the fasting mimicking diet or is three really kind of ideal?

squadcaster-4i9i_1_09-05-2024_100649: 32:43

if I'll give you a couple of profiles, right? for example, you, Jeff, right? You seem, you know, metabolically, you seem healthy, and, and if you say, I want to do prolon, fasting, for my, bio age to reverse my bio age. Then you can do it three times. If you say, look, Okay. I carry a little bit more weight or I have cholesterol. I have a blood pressure issue. I have triglyceride. You have a metabolic reason to correct, Then you start adding the frequency. for pre diabetes, we recommend you do four times per year in what we call metabolic syndrome. And for diabetes, we have done two very successful trials, one in Germany and one in Holland. they both have the same, protocol. Do it once a month for six months because you have a health condition. You want to get it into remission or regression. So you do month one, two, three, four, five, six. Then you go into maintenance the same as we talked about once every three or four months just to maintain. So the frequency comes if you want to lose more weight or if you have a health condition, then you can increase the frequency.

jeff_1_09-05-2024_100648: 33:45

And you've kind of alluded to a little bit of this, but there are any specific age groups or health conditions that will see the most significant benefits?

squadcaster-4i9i_1_09-05-2024_100649: 33:53

I think. Diabetes type 2 and pre diabetes and blood pressure, the metabolic slash aging factors because you have, you know, with prolon or the fasting mimicking diet, as we said, you lose a lot of fat pretty fast. You protect your muscle and you're reversing the bio age of the cells. And this is a very big intervention for diabetes. We're studying cancer as well, and I don't want to reveal early data because not published. But we have very encouraging data on optimizing how the body deals with chemo or immune therapy. When you do the fasting, we can die with those. We're gonna publish that soon, and then we'll reveal those results. Autoimmune diseases, Stanford and University of Miami will will they actually finished their trials? They're going to publish it soon. But the theory there is well known with fasting in the old books of autoimmune diseases. People with psoriasis, lupus, rheumatoid arthritis, Crohn's, UCI, and Hashimoto. What they have is an immune system that's attacking one of the organs. when you fast, the immune system cannot replicate and keep doing the attack because it spends calories. the body shuts down the attack and Cannot sustain high temperature because it's all calorie expenditures that you cannot afford. So the body shuts down the attack very fast and then because of autophagy and rejuvenation after day three, the damage organ is correcting. So there's a big theory on why to do the prolonged fasting. There's actually clinics around the world that where you can go and do a prolonged water fast. Again, we don't recommend it unless you do it in a clinic. If you do it at home, it's the fasting mimicking diet. they can take most chronic, autoimmune diseases and reverse the symptoms because the body doesn't allow an excited immune system to attack when it's fasting and fixes the attacked organ faster than otherwise.

jeff_1_09-05-2024_100648: 35:49

And I'm pretty sure I know the answer to this question, but for the sake of the listener and the viewer, are there any potential risks or side effects associated with the fasting mimicking diet that people should be aware of?

squadcaster-4i9i_1_09-05-2024_100649: 36:01

there are three things to watch out with it. If you're. You know, very old and frail, right? Say you're already very frail and or you're very old and you have a lot of health conditions. We don't want you to go and fast for five days or you have a very low BMI. If you have allergies to the ingredients, like any other food, if you have allergies to food, then we don't want you to, to go and do that. And if you're growing something, so you're pregnant, growing a baby or lactating, we don't want you to be fasting while you're same way. If you're like 10 years old, 12 years old, below age. 18 to 20 and you're still growing vertically. You're not prone to age related diseases. There's no reason to fast at that age. So these will be the profiles that should not necessarily consider the fasting mimicking diet.

jeff_1_09-05-2024_100648: 36:47

this is a question that just popped into my head. I have a son who is Pursuing a career in MMA. he's opted to move down the weight class. he wrestled heavyweight in high school

squadcaster-4i9i_1_09-05-2024_100649: 36:57

Yeah.

jeff_1_09-05-2024_100648: 36:58

he started his MMA career at light Heavyweight at 2 0 5 and his move down, his last fight was at middleweight at, at 180 5 and he did a, you know, smart scientific cut. But is there any benefit in the athletic population where maybe they're in a sport Associated with weight. I still do strength and conditioning with the local

squadcaster-4i9i_1_09-05-2024_100649: 37:18

100%. I cannot mention names because they're celebrities, but I can tell you that there's the people want to cut fat the most and protect muscle the most are the cyclists. Right, because any extra fat will slow them and they need to preserve the muscles. the Olympic gold medalist, not, not this time last, you know, I don't wanna mention, but they used to do ProLon for that. And then, a lot of the N-F-L-N-B-A players off season, when they're on season, they, they, they cannot, they cannot fast where they need seven, 8,000, you know, but if they're injured. and or an off season. They want to lose the summer fat and and and keep the muscle. They and again, I cannot drop names, but we're talking about the bigger, biggest names. they use prolon for that. how old is your son?

jeff_1_09-05-2024_100648: 38:09

He's 19

squadcaster-4i9i_1_09-05-2024_100649: 38:10

So there's no medical reason to do it, but if it's purely lose the weight, lose the fat and protect muscle, we have full clinical trials that we did on young men, adult to prove because that's the population that always gets scared from fasting. He's like, Hey, I don't want to lose muscle. And we did a full clinical trial, randomized on, fasting and diet muscle protection. it shows that you protect muscle and shed fat. they protect muscle function and you shed fat a lot of athletes, they do it when they're injured. They, when they are, they carrying a little bit more fat, this is professional athletes. Now. People are 40 and above, and they're, they're going to the gym for healthy aging, and they start developing any metabolic condition, or they're finding it difficult to lose weight. Definitely, like, the, the fasting mimicking diet is critical at that age. Women that hit menopause, you know, menopause, it's a biological switch. They start gaining weight. They're starting, the skin changes. You asked me about the benefit. We see prolonged impact on the body, and, and, and we did a randomized clinical trial on skin rejuvenation. And we showed that there's better skin hydration and rejuvenation when you do the fasting, when we can die. I mean, imagine you're eating food and we took the risk and a randomized paper trial that's now published to show that your skin changes. And this is how powerful because every cell is fasting and rejuvenating or almost every cell fasting is so powerful in the cells. so women that had been a pause is very important for them to, to, they start gaining weight, increasing cholesterol, blood pressure. And men, obviously, between age 40 and 65, 70, same thing, resistant belly fat, losing muscle, increasing inflammation, what we call the inflammation in the body. So, during the prolonged fasting mimicking diet at those ages, that's the golden critical age for it.

jeff_1_09-05-2024_100648: 39:53

What are the future directions for? Research and development in the field of fasting and aging anything new on the horizon you want to share?

squadcaster-4i9i_1_09-05-2024_100649: 40:03

Yeah, for sure, I mean, we keep doing new clinical trials. we think the fasting mimicking diet, as a platform to rejuvenate cells could have benefits and impact. We like to pair the short term health condition with longevity, right? so we show how it improves on the short term, the system and longevity. So we test it for obesity, for prediabetes, for diabetes. we're in multiple clinical trials on cancer, on Alzheimer's, on autoimmune, but what we like the most is that at any age, what we try to do and what our research is trying to show. is we want to keep you younger than your age. Let's go back to how we started. And the goal is to give you a nutritional and it's five days only. Again, we're not asking people to be on a diet every day. This is not a diet. This is science. It's just five days a month to help you or a quarter even five days a quarter. And anyone could do that. It is difficult on day three. So again, You're going into a bankruptcy and a rejuvenation of the cells. So you, day three will be a little bit, you feel the transition, you feel the emotional, it's an emotional transformation as well. But at least having your bio age of the cells a little bit backwards is what we love about helping people with longevity through rejuvenation.

jeff_1_09-05-2024_100648: 41:21

And we are actually, an affiliate with TruDiagnostic who does epigenetic testing. I'm just wondering, would you encourage somebody, if they can afford it and it kind of fits into their, their budget and their plan, tie in some epigenetic testing with this diet so that they can actually see what's

squadcaster-4i9i_1_09-05-2024_100649: 41:40

Yes.

jeff_1_09-05-2024_100648: 41:40

what organ systems are being affected,

squadcaster-4i9i_1_09-05-2024_100649: 41:42

Yeah. we like Tru Diagnostic and Ryan and I are good friends. what True Diagnostic did really well is they applied different types of age measurement, right? You have the, the, the Horvath and the telomeres, then you have the epigenetics, then you have the phenotypes. So, what responds the most if people want to measure their bio age, this is a bio age score that was developed by Morgan Levin at Yale and USC at true age, it's the phenotype bio age, which relies on, CRP, cholesterol, albumin, alkaline phosphatase, and cholesterol in the blood. And this is the only test that is based on a true chronological, Longevity trial. the U. S. Government has been sponsoring a trial called the NHANES study, and few people know about it, but we're on the year 22 or 23 now already. So 23 years they've been following 9400 plus people. I forgot the exact number. So we have one longevity trial in the world sponsored by the U. S. Government, tracking 9000 people for now 23 years. Some of them died, some had cancer, some are healthy, some had diabetes. So this trial allows us to look at their blood measurement every year and understand who develops what and who dies early and not. So Yale and USC got together and reverse engineered the data to come up with a phenotype, phenotypic or blood aging measurement. It doesn't rely on epigenetics or telomeres, it just tells you based on your blood metrics today, They found five very important metrics, CRP, cholesterol, aldumin, phosphatase, alkaline, they also measure your weight and age, and then they'll tell you the delta between your biological age and phenotypic age. this is the test we use with Prolon, and it shows you the benefits fast. for those, who want to measure, they can measure that bio age say you do three Prolons, and then you can measure your bio age and get the results.

jeff_1_09-05-2024_100648: 43:35

our guests, what are you doing personally to age well other than fasting mimicking three times a year.

squadcaster-4i9i_1_09-05-2024_100649: 43:42

So definitely the prolon three times. I do the circadian intermittent fasting. for me, 12 to 14 hours is very important. I used to, based on my work, eat late at night and then fast the entire next day. Now I definitely try to, finish food at six max seven. a lot of people are trying to finish even earlier, right? There's, I don't know how much. There is a need to eat late at night, so I definitely try to do that. We have other products that I consume. I get my proteins, for example, from, a longevity protein shake. called the L protein. I do that as my main source because it's fully vegan. It's clean sourcing. sometimes I do the fast bar in the morning for breakfast. But a practice of intermittent fasting and fast bar, I try to be, pescetarian. I'm mainly plant based, a little bit of fish, sometimes flexitarian. I do get two or three times a month, red meat. I am between that 40 to 65 category. So I don't eat a lot of red meat or chicken in this age. You should eat more once you're after 65, more red meat or chicken, but at this pre disease or onset of disease, cancer is formed between age 40 and 65 and the plaques in your hearts and your coronaries are formed now. I mean, they're always, but they get accelerated now with high inflammation rate. This is when you can get acute heart attack. So I try to be as much as possible between flexitarian and pescetarian. I do exercise every day. I try to reach my 10, 000. I cannot do it all the time, but I try to, I don't take Any of the supplements that are, you know, there are an A. D. Or N. M. N. Or, you know, I'm still looking at the data for those. I know there's a potential there, but I haven't seen large human data on safety. So maybe they're good. Maybe not. I feel like the five pillars that I practice, as we said, nutrition, exercise, stress, sleep and the social capital and the purpose. I think those are the major determinants of it. Reaching the longevity potential in a natural way. this is what I try to focus on.

jeff_1_09-05-2024_100648: 45:43

Anything we missed?

squadcaster-4i9i_1_09-05-2024_100649: 45:46

I think this is a great, podcast. We promised to change somebody's life today. after discussion, shedding light on a lot of topics to summarize three times fasting and vegan diet dinner is probably the biggest villain among foods. try to have it early and light almost no dinner. practice the circadian 12 hours to 14 hours intermittent fasting. these are major determinants of health. We study people living 100 and beyond centenarians. I can tell you none of them was, overeating in their life or eating frequently. They all balanced it. That circadian fasting was big for them. And then happiness, right? This, you mentioned on purpose, I say, I call it social capital, happiness, purposefulness, friends and family be well nested. Happiness is with nutrition is the mother of all good behavior. When you're happy and serene, you exercise, you eat better, you sleep better, you stress less. So focusing on nutrition and the happiness factor I think is a lot, a lot of things in life and longevity.

jeff_1_09-05-2024_100648: 46:46

Great. Dr. Anton, thank you for joining us today. how can the listener or the viewer learn more about El Nutra, and the fasting mimicking diet? You mentioned the website. Maybe you can repeat that again. Is there any social media that we should know about?

squadcaster-4i9i_1_09-05-2024_100649: 47:01

If you want to read about the company in general, the mission and the science, you can go to Lnutra. com L for longevity dash Nutra. and utra. com. If you want to read specifically about the fasting mimicking diet and the product, you can visit prolonlife. com. Prolon is P R O L O N, life. com. if you have a health condition and you want to be coached with our doctors and dieticians and use the fasting mimicking diet, you can go to alnutrahealth. com. This is our healthcare division in the company, alnutrahealth. com. If you want to follow me personally, I'm very active on LinkedIn. And now, you know, it's with X and it's, under all of them at drjosephanton. com.

jeff_1_09-05-2024_100648: 47:42

we'll include all those links again. And so, again, thank you for joining us and sharing about the Fasting Mimicking Diet. And, as always, keep aging well.

squadcaster-4i9i_1_09-05-2024_100649: 47:52

Thank you, Jeff.

47:54

Thank you for listening. I hope you benefited from today's podcast. Until next time, keep aging well.